
Salvianolic acid A
CAS No. 96574-01-5
Salvianolic acid A ( Dan Phenolic Acid A )
产品货号. M19895 CAS No. 96574-01-5
丹酚酸A可以通过抑制基质金属肽酶9(MMP-9)和抗炎来保护血脑屏障。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥365 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥1183 | 有现货 |
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50MG | ¥1758 | 有现货 |
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100MG | ¥2641 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Salvianolic acid A
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述丹酚酸A可以通过抑制基质金属肽酶9(MMP-9)和抗炎来保护血脑屏障。
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产品描述Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.(In Vivo):A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain.
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体外实验——
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体内实验A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain.
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同义词Dan Phenolic Acid A
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通路Metabolic Enzyme/Protease
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靶点MMP
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受体MMP-9
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研究领域Metabolic Disease
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适应症Diabetes
化学信息
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CAS Number96574-01-5
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分子量494.45
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分子式C26H22O10
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纯度>98% (HPLC)
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溶解度DMSO:130 mg/mL; Ethanol:10 mg/mL
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SMILESOC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhang W et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation. Chin J Nat Med. 2018 Mar;16(3):184-193.
产品手册




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